New and recently funded Medical Startups
1
Country: USA | Funding: $253.7M
Imvax develops personalized immunotherapeutic cancer vaccines against glioblastoma and other solid tumors that are created from the patient's own tumor cells. Imvax's Goldspire platform delivers a combo of patient-derived tumor cells and an antisense oligodeoxynucleotide (IMV-001) against the insulin-like growth factor receptor type 1 (IGF-1R). This combination is loaded into implantable, proprietary biodiffusion chambers. This technology is designed to provide both innate and adaptive immune stimulation to overcome the challenges associated with the variability of solid tumors and their ability to suppress the immune system. Imvax is developing a diverse portfolio of drugs against glioblastoma, endometrial cancer, hepatocellular carcinoma, urothelial cancer and ovarian cancer.
Imvax develops personalized immunotherapeutic cancer vaccines against glioblastoma and other solid tumors that are created from the patient's own tumor cells. Imvax's Goldspire platform delivers a combo of patient-derived tumor cells and an antisense oligodeoxynucleotide (IMV-001) against the insulin-like growth factor receptor type 1 (IGF-1R). This combination is loaded into implantable, proprietary biodiffusion chambers. This technology is designed to provide both innate and adaptive immune stimulation to overcome the challenges associated with the variability of solid tumors and their ability to suppress the immune system. Imvax is developing a diverse portfolio of drugs against glioblastoma, endometrial cancer, hepatocellular carcinoma, urothelial cancer and ovarian cancer.
2
Country: China | Funding: $370M
D3 Bio specializes in the development of innovative immunotherapies in oncology and immunology. The company's lead drug, elisrasib, is a next-generation KRAS G12C inhibitor that is being studied as a potential monotherapy for non-small cell lung cancer and metastatic colorectal cancer, as well as in combination with Merck KGaA's Erbitux anticancer drug or with immune checkpoint inhibitors. The company's pipeline includes clinical trials against mut cancers, CRC, PanCa, breast cancer, gastric cancer, bladder cancer and other solid tumors.
D3 Bio specializes in the development of innovative immunotherapies in oncology and immunology. The company's lead drug, elisrasib, is a next-generation KRAS G12C inhibitor that is being studied as a potential monotherapy for non-small cell lung cancer and metastatic colorectal cancer, as well as in combination with Merck KGaA's Erbitux anticancer drug or with immune checkpoint inhibitors. The company's pipeline includes clinical trials against mut cancers, CRC, PanCa, breast cancer, gastric cancer, bladder cancer and other solid tumors.
3
Country: USA | Funding: $337M
Alaunos Therapeutics develops immunotherapies for cancer treatment using novel TCR-derived T cells. These cell therapies target neoantigens (neoAgs) arising from genomic mutations in solid tumors. The company has developed proprietary, rapid and cost-effective solutions for the delivery of tumor-specific killer T cells. Alaunos' clinical TCR library targets the most common mutations in the KRAS, TP53 and EGFR genes, which are prevalent in gastrointestinal (colon, bile duct, pancreatic), lung and gynecologic (ovarian and endometrial) cancers across a range of different HLA alleles. Company's propriety non-viral Sleeping Beauty transposon/transposase system is used to introduce the TCR gene into the patient's autologous T cells. Alaunos's current pipeline includes clinical trials against lung, colorectal, pancreatic and ovarian cancers.
Alaunos Therapeutics develops immunotherapies for cancer treatment using novel TCR-derived T cells. These cell therapies target neoantigens (neoAgs) arising from genomic mutations in solid tumors. The company has developed proprietary, rapid and cost-effective solutions for the delivery of tumor-specific killer T cells. Alaunos' clinical TCR library targets the most common mutations in the KRAS, TP53 and EGFR genes, which are prevalent in gastrointestinal (colon, bile duct, pancreatic), lung and gynecologic (ovarian and endometrial) cancers across a range of different HLA alleles. Company's propriety non-viral Sleeping Beauty transposon/transposase system is used to introduce the TCR gene into the patient's autologous T cells. Alaunos's current pipeline includes clinical trials against lung, colorectal, pancreatic and ovarian cancers.
4
Country: USA | Funding: $100M
Triumvira Immunologics is an immunotherapy company with the vision of developing novel T cell therapies that are safer and more efficacious than current cancer treatments, including chimeric antigen receptor (CAR) and engineered T cell receptor (TCR) therapies. Their proprietary T cell Antigen Coupler (TAC) technology recruits the entire natural T cell receptor and is independent of the major histocompatibility complex (MHC), allowing for the development of better therapies for a broader range of patients with solid or liquid malignancies and also with diseases other than cancer.
Triumvira Immunologics is an immunotherapy company with the vision of developing novel T cell therapies that are safer and more efficacious than current cancer treatments, including chimeric antigen receptor (CAR) and engineered T cell receptor (TCR) therapies. Their proprietary T cell Antigen Coupler (TAC) technology recruits the entire natural T cell receptor and is independent of the major histocompatibility complex (MHC), allowing for the development of better therapies for a broader range of patients with solid or liquid malignancies and also with diseases other than cancer.
5
Country: USA
Medical Edge Solutions produces advanced medical equipment tailored to healthcare professionals’ needs. Its products include cutting-edge diagnostic and vestibular testing tools, the TM Flow System for TMJ disorder care, portable C-arm X-ray machines for flexible imaging, and knee therapy machines for optimized rehabilitation.
Medical Edge Solutions produces advanced medical equipment tailored to healthcare professionals’ needs. Its products include cutting-edge diagnostic and vestibular testing tools, the TM Flow System for TMJ disorder care, portable C-arm X-ray machines for flexible imaging, and knee therapy machines for optimized rehabilitation.
6
Country: USA | Funding: $614.6M
Neumora Therapeutics develops precision therapies for treatment of brain diseases. Its uses the propriety platform Precision Toolbox, which includes a suite of translational, medical and computational tools for information discovery, capable of applying precision medicine approaches. Its therapeutic portfolio includes seven programs for the treatment of neuropsychiatric disorders and neurodegenerative diseases (major depressive disorder, Alzheimer's disease, schizophrenia, and Parkinson's disease). Neumora's lead program, navacaprant, is a novel, highly selective kappa opioid receptor (KOR) antagonist nearing the end of development as a reliable monotherapy for the treatment of MDD. Navacaprant is an investigational, once-daily oral medication designed to modulate dopamine and reward signaling pathways, which play a critical role in the regulation of mood, cognition, reward and behavior.
Neumora Therapeutics develops precision therapies for treatment of brain diseases. Its uses the propriety platform Precision Toolbox, which includes a suite of translational, medical and computational tools for information discovery, capable of applying precision medicine approaches. Its therapeutic portfolio includes seven programs for the treatment of neuropsychiatric disorders and neurodegenerative diseases (major depressive disorder, Alzheimer's disease, schizophrenia, and Parkinson's disease). Neumora's lead program, navacaprant, is a novel, highly selective kappa opioid receptor (KOR) antagonist nearing the end of development as a reliable monotherapy for the treatment of MDD. Navacaprant is an investigational, once-daily oral medication designed to modulate dopamine and reward signaling pathways, which play a critical role in the regulation of mood, cognition, reward and behavior.
7
Country: Israel | Funding: $1B
Novocure is developing a new treatment for solid tumors known as tumor polytherapy (TTFields). TTFields are low-intensity alternating electric fields, particularly at intermediate frequencies that disrupt cancer cell division through physical interaction with key molecules during mitosis. TTFields do significantly affect healthy cells, as they have different properties (including division rate, morphology and electrical properties) compared to cancer cells. The company's TTFields pipeline includes therapies against glioblastoma, metastatic non-small cell lung cancer and pancreatic cancer. The company also produces FDA-approved portable devices for the treatment of GB and mNSCLC. These devices also work via creating electric fields that can slow or stop cancer cell division.
Novocure is developing a new treatment for solid tumors known as tumor polytherapy (TTFields). TTFields are low-intensity alternating electric fields, particularly at intermediate frequencies that disrupt cancer cell division through physical interaction with key molecules during mitosis. TTFields do significantly affect healthy cells, as they have different properties (including division rate, morphology and electrical properties) compared to cancer cells. The company's TTFields pipeline includes therapies against glioblastoma, metastatic non-small cell lung cancer and pancreatic cancer. The company also produces FDA-approved portable devices for the treatment of GB and mNSCLC. These devices also work via creating electric fields that can slow or stop cancer cell division.
8
Country: Australia
Amplia Therapeutics develops focal adhesion kinase (FAK) inhibitors for the treatment of pancreatic and ovarian cancer. Focal adhesion kinase (FAK) is expressed in many types of cancer, where it maintains cell viability and stimulates cell growth and migration. Amplia's lead drug candidate, narmafotinib, is a highly selective and potent FAK inhibitor that has shown promising results in pancreatic cancer research. FAK inhibitors act on both the cancer cells themselves and surrounding tissue, making current and future treatments more vulnerable and responsive. Amplia has orphan drug designation, fast-track designation and an open application for pancreatic cancer treatment from the US FDA.
Amplia Therapeutics develops focal adhesion kinase (FAK) inhibitors for the treatment of pancreatic and ovarian cancer. Focal adhesion kinase (FAK) is expressed in many types of cancer, where it maintains cell viability and stimulates cell growth and migration. Amplia's lead drug candidate, narmafotinib, is a highly selective and potent FAK inhibitor that has shown promising results in pancreatic cancer research. FAK inhibitors act on both the cancer cells themselves and surrounding tissue, making current and future treatments more vulnerable and responsive. Amplia has orphan drug designation, fast-track designation and an open application for pancreatic cancer treatment from the US FDA.
9
Country: Belgium | Funding: €4M
ElmediX is developing thermotherapy for the treatment of pancreatic cancer. This treatment method involves raising the patient's body temperature to 41.5°C for a period of time to strengthen the immune system, suppress tumor growth and enhance sensitivity to other anticancer drugs. Thermotherapy is toxic to cells in a hypoxic, low-pH environment, particularly typical of tumor tissue, due to insufficient blood perfusion. Heat increases permeability and blood flow in the tumor stroma, enhancing oxidative damage to cancer cells and the resorption of anticancer drugs by cancer cells. This enhances the effectiveness of chemotherapy and has been demonstrated in several recent clinical trials.
ElmediX is developing thermotherapy for the treatment of pancreatic cancer. This treatment method involves raising the patient's body temperature to 41.5°C for a period of time to strengthen the immune system, suppress tumor growth and enhance sensitivity to other anticancer drugs. Thermotherapy is toxic to cells in a hypoxic, low-pH environment, particularly typical of tumor tissue, due to insufficient blood perfusion. Heat increases permeability and blood flow in the tumor stroma, enhancing oxidative damage to cancer cells and the resorption of anticancer drugs by cancer cells. This enhances the effectiveness of chemotherapy and has been demonstrated in several recent clinical trials.
10
Country: German | Funding: $20M
TaxolCur develops new approach to treat cancer using to HYBRID-NANOENGINEERING attack on tumor stem cells and microenvironment in one formulation.
TaxolCur develops new approach to treat cancer using to HYBRID-NANOENGINEERING attack on tumor stem cells and microenvironment in one formulation.
